Identification of Streptococcus pneumoniae genes associated with hypothiocyanous acid tolerance through genome-wide screening
October 4, 2023
Heather L. Shearer, Paul E. Pace, Leah M. Smith, Peter C. Fineran, Allison J. Matthews, Andrew Camilli, Nina Dickerhof, Mark B. Hampton
Moving beyond mortality: Development and Application of a Desirability of Outcome Ranking (DOOR) Endpoint for Hospital-Acquired Bacterial Pneumonia and Ventilator-Associated Bacterial Pneumonia
September 22, 2023
Hospital-acquired and ventilator-associated bacterial pneumonia (HABP/VABP) are frequently caused by multidrug-resistant organisms. Patient-centered endpoints in clinical trials are needed to develop new antibiotics for HABP/VABP. Desirability of outcome ranking (DOOR) is a paradigm for the design, analysis, and interpretation of clinical trials based on a patient-centered, benefit-risk evaluation.
A US-based national surveillance study for the susceptibility and epidemiology of Clostridioides difficile isolates with special reference to ridinilazole: 2020–2021
September 20, 2023
D. R. Snydman, L. A. McDermott, C. M. Thorpe, E. J. C. Goldstein, A. N. Schuetz, S. Johnson, D. N. Gerding, L. Gluck, D. Bourdas, K. C. Carroll, C. K. Lancaster, K. W. Garey, Q. Wang, S. T. Walk, E. Duperchy
Checklist for studies of HIV drug resistance prevalence or incidence: rationale and recommended use
September 13, 2023
HIV drug resistance (HIVDR) is a major challenge to the effectiveness of antiretroviral therapy. Global efforts in addressing HIVDR require clear, transparent, and replicable reporting in HIVDR studies. We describe the rationale and recommended use of a checklist that should be included in reports of HIVDR incidence and prevalence. After preliminary consultations with experts on HIVDR and establishing the need for guidance on HIVDR reporting, we used a sequential, explanatory, mixed methods approach to create the checklist; together with the accompanying articles, the checklist was reviewed by the authors and validated externally. The checklist for studies on HIVDR prevalence or incidence (CEDRIC-HIV) includes 15 recommended items that would enhance transparency and facilitate interpretation, comparability, and replicability of HIVDR studies. CEDRIC-HIV will help authors of HIVDR studies prepare research reports and assist reviewers and editors in assessments of completeness of reporting. The checklist will also facilitate statistical pooling and interpretation of HIVDR data.
Leveraging the COVID-19 pandemic as a natural experiment to assess changes in antibiotic use and antibiotic-resistant E. coli carriage in semi-rural Ecuador
September 8, 2023
Heather K. Amato, Fernanda Loayza, Liseth Salinas, Diana Paredes, Daniela García, Soledad Sarzosa, Carlos Saraiva-Garcia, Timothy J. Johnson, Amy J. Pickering, Lee W. Riley, Gabriel Trueba & Jay P. Graham
Exploration of a Potential Desirability of Outcome Ranking Endpoint for Complicated Intra-Abdominal Infections Using 9 Registrational Trials for Antibacterial Drugs
August 22, 2023
Tori Kinamon, Ramya Gopinath, Ursula Waack, Mark Needles, Daniel Rubin, Deborah Collyar, Sarah B Doernberg, Scott Evans, Toshimitsu Hamasaki, Thomas L Holland, Jessica Howard-Anderson, Henry Chambers, Vance G Fowler, Jr, Sumati Nambiar, Peter Kim, Helen W Boucher
Interactions of Vibrio phages and their hosts in aquatic environments
August 10, 2023
Roberto C Molina-Quiroz, Cecilia A Silva-Valenzuela,
Bacteriophages (phages) are viruses that specifically infect bacteria. These viruses were discovered a century ago and have been used as a model system in microbial genetics and molecular biology. In order to survive, bacteria have to quickly adapt to phage challenges in their natural settings. In turn, phages continuously develop/evolve mechanisms for battling host defenses. A deeper understanding of the arms race between bacteria and phages is essential for the rational design of phage-based prophylaxis and therapies to prevent and treat bacterial infections. Vibrio species and their phages (vibriophages) are a suitable model to study these interactions. Phages are highly ubiquitous in aquatic environments and Vibrio are waterborne bacteria that must survive the constant attack by phages for successful transmission to their hosts. Here, we review relevant literature from the past two years to delve into the molecular interactions of Vibrio species and their phages in aquatic niches.
Prevalence of antibiotic use for dogs and cats in United States veterinary teaching hospitals, August 2020
August 1, 2023
Awareness of prescribing practices helps identify opportunities to improve antibiotic use (AU).
Chemical QuantArray: A Quantitative Tool for Mass Spectrometry Imaging
July 19, 2023
Sylwia A. Stopka, Daniela Ruiz, Gerard Baquer, Clément Bodineau, Md Amin Hossain, Valentina T. Pellens, Michael S. Regan, Olivier Pourquié, Marcia C. Haigis, Wenya L. Bi, Shannon M. Coy, Sandro Santagata, Nathalie Y. R. Agar, and Sankha S. Basu
Applying Desirability of Outcome Ranking End Points
July 1, 2023
Michael W Dunne, Steven I Aronin, Anita F Das, Jayanti Gupta, Karthik Akinapelli, Michael T Zelasky, Sailaja Puttagunta, Helen W Boucher
- Strain diversity drives heterogeneous responses to tuberculosis combination therapyMay 15, 2026
- A New Era for Global Environmental Surveillance of Infectious DiseaseApril 30, 2026
- Restoration of daptomycin sensitivity with adjunctive cefazolin is associated with C-terminal MprF mutations in MRSA bacteremia isolatesApril 27, 2026
- An RNA-to-RNA Pipeline for Rapid Antiviral Antibody DevelopmentApril 9, 2026
- Antibiotic dose-response curves can measure antibiotic activity against Mycobacterium abscessus and Mycobacterium peregrinumApril 6, 2026