RESTORE-IMI 1: A Multicenter, Randomized, Double-blind Trial Comparing Efficacy and Safety of Imipenem/Relebactam vs Colistin Plus Imipenem in Patients With Imipenem-nonsusceptible Bacterial Infections
August 10, 2019
Clin Infect Dis. 2019 Aug 10. pii: ciz530.
Acinetobacter baumannii: Envelope determinants that control drug resistance, virulence, and surface variability
June 14, 2019
Edward Geisinger, Wenwen Huo, Juan Hernandez-Bird, and Ralph R. Isberg. Annual Review of Microbiology Vol. 73:- (Volume publication date September. 2019); Review in Advance first posted online on June 14, 2019. (Changes may still occur before final publication.
Sequential, Multiple-Assignment, Randomized Trials for COMparing Personalized Antibiotic StrategieS (SMART-COMPASS)
May 17, 2019
Evans, S. R., D. Follmann, Y. Liu, T. Holland, S.B. Doernberg, N. Rouphael, T. Hamasaki, Y. Jiang, J. J. Lok, T.T.T. Tran, A.D. Harris, V.G. Fowler Jr, H. Boucher, B.N. Kreiswirth, R.A. Bonomo, D. van Duin, D.L. Paterson, and H. Chambers. Clin Infect Dis. 2019 May 17;68(11):1961-1967.
Promises and Challenges of the Type Three Secretion System Injectisome as an Antivirulence Target
February, 2019
Antibiotic resistance is a major public health threat that has stimulated the scientific community to search for nontraditional therapeutic targets. Because virulence, but not the growth, of many Gram-negative bacterial pathogens depends on the multicomponent type three secretion system injectisome (T3SSi), the T3SSi has been an attractive target for identifying small molecules, peptides, and monoclonal antibodies that inhibit its function to render the pathogen avirulent.
Provincial and National Prevalence Estimates of Transmitted HIV-1 Drug Resistance in South Africa Measured Using Two WHO-Recommended Methods
February 11, 2019
Gillian M Hunt, Johanna Ledwaba, Monalisa Kalimashe, Anna Salimo, Siyabonga Cibane, Beverly Singh, Adrian Puren, Natalie Exner Dean, Lynn Morris, Michael R Jordan. Antivir Ther. 2019;24(3):203-21.
Potassium Response and Homeostasis in Mycobacterium Tuberculosis Modulates Environmental Adaptation and is Important for Host Colonization
February 4, 2019
Nathan J. MacGilvary, Yuzo L. Kevorkian, and Shumin Tan. PLoS Pathog. 2019 Feb 4;15(2):e1007591.
Prediction of ultra-high-order antibiotic combinations based on pairwise interactions
January 30, 2019
Itay Katzir, Murat Cokol, Bree B. Aldridge, and Uri Alon. PLoS Comput Biol 15(1): e1006774.
Parenterally Administered Vancomycin in 29 Dogs and 7 Cats (2003-2017)
January, 2019
Ian M. DeStefano Annie S. Wayne Elizabeth A. Rozanski Jonathan M. Babyak
Prophage induction, but not production of phage particles, is required for lethal disease in a microbiome-replete murine model of enterohemorrhagic E. coli infection.
Jan, 2019
Enterohemorrhagic Escherichia coli (EHEC) colonize intestinal epithelium by generating characteristic attaching and effacing (AE) lesions. They are lysogenized by prophage that encode Shiga toxin 2 (Stx2), which is responsible for severe clinical manifestations.
Partial Oral Therapy for Osteomyelitis and Endocarditis - Is It Time?
Jan, 2019
Antimicrobial resistance threatens health and global security, with an estimated 162,000 deaths per year in the United States caused by multidrug-resistant infections
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