Parenterally Administered Vancomycin in 29 Dogs and 7 Cats (2003-2017)
January, 2019
Ian M. DeStefano Annie S. Wayne Elizabeth A. Rozanski Jonathan M. Babyak
Prophage induction, but not production of phage particles, is required for lethal disease in a microbiome-replete murine model of enterohemorrhagic E. coli infection.
Jan, 2019
Enterohemorrhagic Escherichia coli (EHEC) colonize intestinal epithelium by generating characteristic attaching and effacing (AE) lesions. They are lysogenized by prophage that encode Shiga toxin 2 (Stx2), which is responsible for severe clinical manifestations.
Partial Oral Therapy for Osteomyelitis and Endocarditis - Is It Time?
Jan, 2019
Antimicrobial resistance threatens health and global security, with an estimated 162,000 deaths per year in the United States caused by multidrug-resistant infections
Synthesis of the Non-Reducing Hexasaccharide Fragment of Saccharomicin B
November 14, 2018
ACS Publications, Organic Letters, 2018 Nov 14. doi: 10.1021/acs.orglett.8b03333
An Experimental Pipeline for Initial Characterization of Bacterial Type III Secretion System Inhibitor Mode of Action Using Enteropathogenic Yersinia
November, 2018
Dozens of Gram negative pathogens use one or more type III secretion systems (T3SS) to disarm host defenses or occupy a beneficial niche during infection of a host organism.
Good Studies Evaluate the Disease While Great Studies Evaluate the Patient: Development and Application of a Desirability of Outcome Ranking Endpoint for Staphylococcus aureus Bloodstream Infection
October 12, 2018
Sarah B Doernberg, Thuy Tien Tram Tran, Steven Y C Tong, Mical Paul, Dafna Yahav, Joshua S Davis, Leonard Leibovici, Helen W Boucher, G Ralph Corey, Sara E Cosgrove, Henry F Chambers, Vance G Fowler, Scott R Evans, Thomas L Holland,
The PARE Project: A Short Course-Based Research Project for National Surveillance of Antibiotic-Resistant Microbes in Environmental Samples
October 31, 2018
Course-based research experiences (CREs) have been proposed as an inclusive model to expose all students, including those at institutions without a strong research infrastructure, to research at an early stage.
The landscape of intrinsic and evolved fluoroquinolone resistance in Acinetobacter baumannii includes suppression of drug-induced prophage replication
October, 2018
The emergence of fluoroquinolone resistance in nosocomial pathogens has restricted the clinical efficacy of this antibiotic class. In Acinetobacter baumannii, the majority of clinical isolates now show high level resistance due to mutations in gyrA (DNA gyrase) and parC (Topo IV).
Microbial Identification Using DNA Target Amplification and Sequencing: Clinical Utility and Impact on Patient Management
October, 2018
Tinzar Basein, Bradley J Gardiner, Gabriela M Andujar Vazquez, Andrew S Joel Chandranesan, Arthur R Rabson, Shira Doron, David R Snydman
Effect of Algorithm-Based Therapy vs Usual Care on Clinical Success and Serious Adverse Events in Patients with Staphylococcal Bacteremia: A Randomized Clinical Trial.
Sep, 2018
Thomas L. Holland, MD, Issam Raad, MD, Helen W. Boucher, MD, et al
- Antibiotic allergy prevalence and documentation quality in Massachusetts long-term care facilities: A cross-sectional surveyJune 17, 2024
- In vitro identification of underutilized β-lactam combinations against methicillin-resistant Staphylococcus aureus bacteremia isolatesJune 25, 2024
- Dipping Your Toe in The CURE Pool: Longitudinal Tracking of Instructors Suggests Use of a Short-Duration CURE Can Catalyze Expansion to Longer CURE ExperiencesJuly 9, 2024
- The impact of 30-day antecedent antibiotic exposure on Clostridioides difficile ribotype patterns and the relationship with clinical outcomes: A single center studyAugust 8, 2024
- Blocking HXA3-mediated neutrophil elastase release during S. pneumoniae lung infection limits pulmonary epithelial barrier disruption and bacteremiaAugust 9, 2024