Caution against using plasma mNGS for NHSN CLABSI surveillance
Sept 22, 2025
We read with interest the recent expansion of the National Healthcare Safety Network (NHSN) surveillance criteria to include non-culture-based testing (NCT), including plasma metagenomic next-generation sequencing (mNGS), in bloodstream infection (BSI) definitions. 1 While mNGS provides diagnostic utility in complex cases, Reference MacIntyre, Hirst, Duttagupta, Hollemon, Hong and Blauwkamp2 we have concerns about its integration into healthcare-associated infection (HAI) surveillance frameworks such as NHSN, where standardization, reproducibility, and clinical relevance are essential.
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Megan W Tse, Meilin Zhu, Benjamin Peters, Efrat Hamami, Julie Chen, Kathleen P Davis, Samuel Nitz, Juliane Weller, Thulasi Warrier, Diana K Hunt, Yoelkys Morales, Tomohiko Kawate Jeffrey L Gaulin, Jon H Come, Juan Hernandez-Bird, Wenwen Huo, Isabelle Neisewander, Xiao Yu, Jose A Aceves-Salvador, Laura L Kiessling, Deborah T Hung, Joan Mecsas, Bree B Aldridge, Ralph R Isberg #, Paul C Blainey # (#=equal contribution)
Proc Natl Acad Sci U S A. 2025 Apr;122(13):e2402017122. doi: Epub 2025 Mar 24.
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Janice J N Goh, Anu Patel, Bernard Ngara, Rob C van Wijk, Natasha Strydom, Qianwen Wang, Nhi Van, Tracy M Washington, Eric L Nuermberger, Bree B Aldridge, et al
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