Interplay Between Antibiotic Resistance and Virulence During Disease Promoted by Multidrug-Resistant Bacteria.
February, 2017
Diseases caused by antibiotic-resistant bacteria in hospitals are the outcome of complex relationships between several dynamic factors, including bacterial pathogenicity, the fitness costs of resistance in the human host, and selective forces resulting from interventions such as antibiotic therapy. The emergence and fate of mutations that drive antibiotic resistance are governed by these interactions. In this review, we will examine how different forms of antibiotic resistance modulate bacterial fitness and virulence potential, thus influencing the ability of pathogens to evolve in the context of nosocomial infections. We will focus on 3 important multidrug-resistant pathogens that are notoriously problematic in hospitals: Pseudomonas aeruginosa, Acinetobacter baumannii, and Staphylococcus aureus. An understanding of how antibiotic resistance mutations shape the pathobiology of multidrug-resistant infections has the potential to drive novel strategies that can control the development and spread of drug resistance.
White Paper: Developing Antimicrobial Drugs for Resistant Pathogens, Narrow-Spectrum Indications, and Unmet Needs.
July 15, 2017
Helen W Boucher, Paul G Ambrose, H F Chambers, Richard H Ebright, Amanda Jezek, Barbara E Murray, Jason G Newland, Belinda Ostrowsky, and John H Rex on behalf of the Infectious Diseases Society of America
Innate Immunity to Intracellular Pathogens: Balancing Microbial Elimination and Inflammation
August 9, 2017
Gabriel Mitchell and Ralph R. Isberg
The therapeutic efficacy of azithromycin and nitazoxanide in the acute pig model of Cryptosporidium hominis
October 3, 2017
Sangun Lee, Melanie Harwood, Don Girouard, Marvin J. Meyers, Mary A. Campbell, Gillian Beamer, Saul Tzipori
Efficient measurement and factorization of high-order drug interactions in Mycobacterium tuberculosis
October 11, 2017
Murat Cokol, Nurdan Kuru, Ece Bicak, Jonah Larkins-Ford and Bree B. Aldridge
Resistance and clonality in Escherichia coli and Klebsiella spp. and relationship with antibiotic consumption in major Lebanese hospitals
December 2017
Ziad Daoud, Elie Salem-Sokhn, Elias Dahdouh, Jihad Irani, Ghassan M. Matar, Shira Doron
Predicting Future Antibiotic Susceptibility using Regression-based Methods on Longitudinal Massachusetts Antibiogram Data
January 2018
M. L. Tlachac, Elke Rundensteiner, Kerri Barton, Scott Troppy, Kirthana Beaulac and Shira Doron
Fucosylated Molecules Competitively Interfere with Cholera Toxin Binding to Host Cells
February 7, 2018
Amberlyn M. Wands, Jakob Cervin, He Huang, Ye Zhang, Gyusaang Youn, Chad A. Brautigam, Maria Matson Dzebo, Per Björklund, Ville Wallenius, Danielle K. Bright, Clay S. Bennett, Pernilla Wittung-Stafshede, Nicole S. Sampson, Ulf Yrlid, and Jennifer J. Kohler
Infectious Diseases Physicians: Leading the Way in Antimicrobial Stewardship
February 12, 2018
Belinda Ostrowsky, Ritu Banerjee, Robert A Bonomo, Sara E Cosgrove, Lisa Davidson, Shira Doron, David N Gilbert, Amanda Jezek, John B Lynch, III, Edward J Septimus, Javeed Siddiqui, and Nicole M Iovine
Evaluation of the In Vitro Activity of Eravacycline against a Broad Spectrum of Recent Clinical Anaerobic Isolates.
Apr, 2018
David R. Snydman, Laura A. McDermott, Nilda V. Jacobus, Kathryn Kerstein, Trudy H. Grossman, Joyce A. Sutcliffe
- EXPRESS: Factors associated with antimicrobial drug prescription in cats receiving outpatient care at a veterinary teaching hospitalJuly 8, 2026
- Loss of essential outer membrane functions causes drug hypersensitization in Acinetobacter baumannii overexpressing multidrug efflux pumpsJune 24, 2026
- Growth arrest of Mycobacterium tuberculosis in acidic environments enhances their survival of antibiotic treatmentJune 22, 2026
- Point-Counterpoint: The “obsoletogram”—are annual hospital antibiograms still relevant?June 10, 2026
- Species-level reporting of Coagulase-negative staphylococci with MALDI-TOF does not impact clinical outcomesMay 25, 2026