Plugging the leaks: antibiotic resistance at human-animal interfaces in low-resource settings
November 1, 2023
Antibiotic resistance is one of the greatest public health challenges of our time. International efforts to curb resistance have largely focused on drug development and limiting unnecessary antibiotic use. However, in areas where water, sanitation, and hygiene infrastructure is lacking, we propose that bacterial flow between humans and animals can exacerbate the emergence and spread of resistant pathogens. Here, we describe the consequences of poor environmental controls by comparing mobile resistance elements among Escherichia coli recovered from humans and meat in Cambodia, a middle-income country with substantial human-animal connectivity and unregulated antibiotic use. We identified identical mobile resistance elements and a conserved transposon region that were widely dispersed in both humans and animals, a phenomenon rarely observed in high-income settings. Our findings indicate that plugging leaks at human-animal interfaces should be a critical part of addressing antibiotic resistance in low- and especially middle-income countries.
A Clinical Model to Predict the Occurrence of Select High-risk Infections in the First Year Following Heart Transplantation
November 2, 2023
Perry, Whitney A. MD, MS; Chow, Jennifer K. MD, MS; Nelson, Jason MPH; Kent, David M. MD, MS; Snydman, David R. MD
Comparative Effectiveness of Fidaxomicin vs Vancomycin in Populations With Immunocompromising Conditions for the Treatment of Clostridioides difficile Infection: A Single-Center Study
December 8, 2023
Majd Alsoubani, Jennifer K Chow, Angie Mae Rodday, David Kent, David R Snydman
Multi-institutional retrospective study investigating blood culture protocols and test positivity in 701 dogs
December 11, 2023
Andrzej J Ogrodny, Rinosh Mani, Sarah M Schmid, Emily N Gould, Claire L Fellman, Ian DeStefano, Sarah Shropshire, Jillian M Haines, Timothy A Bolton, Sara A Jablonski, Nicole Jess, Harry Cridge
In Vitro Pre-Clinical Evaluation of a Gonococcal Trivalent Candidate Vaccine Identified by Transcriptomics
December 13, 2023
Shea K Roe, Brian Felter, Bo Zheng, Sanjay Ram, Lee M Wetzler, Eric Garges, Tianmou Zhu, Caroline A Genco, Paola Massari
Racial differences in testing for infectious diseases: An analysis of jail intake data
December 20, 2023
Alysse G. Wurcel, Rubeen Guardado, Emily D. Grussing, Peter J. Koutoujian, Kashif Siddiqi, Thomas Senst, Sabrina A. Assoumou, Karen M. Freund, Curt G. Beckwith
Streptococcus pneumoniae favors tolerance via metabolic adaptation over resistance to circumvent fluoroquinolones
January 9, 2024
Tina H. Dao, Haley Echlin, Abigail McKnight, Enolia S. Marr, Julia Junker, Qidong Jia, Randall Hayden, Tim van Opijnen, Ralph R. Isberg, Vaughn S. Cooper, Jason W. Rosch
A decade of clinical microbiology: top 10 advances in 10 years: what every infection preventionist and antimicrobial steward should know
January 25, 2024
Tulip A. Jhaveri, Zoe Freeman Weiss, Marisa L. Winkler, Alexander D. Pyden, Sankha S. Basu, Nicole D. Pecora
Effects of breastfeeding on children’s gut colonization with multidrug-resistant Enterobacterales in peri-urban Lima, Peru
February 1, 2024
Maya L. Nadimpalli, Luismarcelo Rojas Salvatierra, Subhra Chakraborty, Jenna M. Swarthout, Lilia Z. Cabrera, Amy J. Pickering, Maritza Calderon, Mayuko Saito, Robert H. Gilman & Monica J. Pajuelo
Diversity and prevalence of zoonotic infections at the animal-human interface of primate trafficking in Peru
February 7, 2024
A. Patricia Mendoza , Ana Muñoz-Maceda, Bruno M. Ghersi, Micaela De La Puente, Carlos Zariquiey, Nancy Cavero, Yovana Murillo, Miguel Sebastian, Yohani Ibañez, Patricia G. Parker, Alberto Perez, Marcela Uhart, Janine Robinson, Sarah H. Olson, Marieke H. Rosenbaum
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- Loss of essential outer membrane functions causes drug hypersensitization in Acinetobacter baumannii overexpressing multidrug efflux pumpsJune 24, 2026
- Growth arrest of Mycobacterium tuberculosis in acidic environments enhances their survival of antibiotic treatmentJune 22, 2026
- Point-Counterpoint: The “obsoletogram”—are annual hospital antibiograms still relevant?June 10, 2026
- Species-level reporting of Coagulase-negative staphylococci with MALDI-TOF does not impact clinical outcomesMay 25, 2026