Which trial do we need? Long-acting glycopeptides versus oral antibiotics for infective endocarditis in patients with substance use disorder
April 9, 2023
Alysse G. Wurcel, Daniel C. DeSimone, Laura Marks, Larry M. Baddour, Parham Sendi
Exploration of a Potential DOOR Endpoint for Complicated Intra-Abdominal Infections Using Nine Registrational Trials for Antibacterial Drugs
April 19, 2023
Tori Kinamon, Ramya Gopinath, Ursula Waack, Mark Needles, Daniel Rubin, Deborah Collyar, Sarah B Doernberg, Scott Evans, Toshimitsu Hamasaki, Thomas L Holland, Jessica Howard-Anderson, Henry Chambers, Vance G Fowler, Jr, Sumati Nambiar, Peter Kim, Helen W Boucher
Penicillium molds impact the transcriptome and evolution of the cheese bacterium Staphylococcus equorum
May 23, 2023
Ruby Ye, Christopher Tomo, Neal Chan, Benjamin E Wolfe
Bacteriophages potentiate the effect of antibiotics by eradication of persister cells and killing of biofilm-forming cells
May 29, 2023
Javiera Vera-Mansilla, Cecilia A Silva-Valenzuela, Patricio Sánchez, Roberto C Molina-Quiroz
Are fermented foods an overlooked reservoir of antimicrobial resistance?
June 5, 2023
Benjamin E. Wolfe
Despite their many cultural, culinary, and health benefits, fermented foods may amplify and disseminate antimicrobial resistance in our food supply. This review summarizes our current understanding of the diversity, distribution, and potential risks of antimicrobial resistance in fermented foods and beverages. Most studies have focused on antibiotic resistance genes (ARGs) in lactic acid bacteria and coagulase-negative Staphylococcus species. Resistance to tetracyclines, penicillins, chloramphenicol, and macrolides is frequently reported. Several studies have demonstrated that ARGs have the potential to be transferred from fermentation microbes to pathogens. Most research has used culture-based or metagenomic surveys or ARGs at the point of production, and few studies have traced the fate of ARGs when ferments are consumed. Cases of humans being directly harmed by resistant microbes in ferments have not been reported, but these foods provide a farm-to-gut pipeline for current and future antimicrobial resistance in our food supply.
Novel Synergies and Isolate Specificities in the Drug Interaction Landscape of Mycobacterium abscessus
June 6, 2023
Nhi Van, Yonatan N. Degefu, Pathricia A. Leus, Jonah Larkins-Ford, Jacob Klickstein, Florian P. Maurer, David Stone, Husain Poonawala, Cheleste M. Thorpe, Trever C. Smith II, Bree B. Aldridge
Establishing a baseline of antibiotic use in Massachusetts jails reveals heterogeneity in quantity of prescriptions and duration of therapy
June 21, 2023
Bart R Szewczyk, Rebecca Tenner, Emily Grussing, Maureen Campion, Gabriela Andujar Vazquez, Tara Bylsma, Shira Doron, Alysse G Wurcel
Evaluating the relationship between community water and sanitation access and the global burden of antibiotic resistance: an ecological study
June 30, 2023
Erica R Fuhrmeister, Abigail P Harvey, Maya L Nadimpalli, Karin Gallandat, Argaw Ambelu, Benjamin F Arnold, Joe Brown, Oliver Cumming, Ashlee M Earl, Gagandeep Kang, Samuel Kariuki, Karen Levy, Chris E Pinto Jimenez, Jenna M Swarthout, Gabriel Trueba, Pablo Tsukayama, Colin J Worby, Amy J Pickering
Applying Desirability of Outcome Ranking End Points
July 1, 2023
Michael W Dunne, Steven I Aronin, Anita F Das, Jayanti Gupta, Karthik Akinapelli, Michael T Zelasky, Sailaja Puttagunta, Helen W Boucher
Chemical QuantArray: A Quantitative Tool for Mass Spectrometry Imaging
July 19, 2023
Sylwia A. Stopka, Daniela Ruiz, Gerard Baquer, Clément Bodineau, Md Amin Hossain, Valentina T. Pellens, Michael S. Regan, Olivier Pourquié, Marcia C. Haigis, Wenya L. Bi, Shannon M. Coy, Sandro Santagata, Nathalie Y. R. Agar, and Sankha S. Basu
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- Growth arrest of Mycobacterium tuberculosis in acidic environments enhances their survival of antibiotic treatmentJune 22, 2026
- Point-Counterpoint: The “obsoletogram”—are annual hospital antibiograms still relevant?June 10, 2026
- Species-level reporting of Coagulase-negative staphylococci with MALDI-TOF does not impact clinical outcomesMay 25, 2026