Publications
November 14, 2018
Publications
Synthesis of the Non-Reducing Hexasaccharide Fragment of Saccharomicin B
ACS Publications, Organic Letters, 2018 Nov 14. doi: 10.1021/acs.orglett.8b03333
November, 2018
Publications
An Experimental Pipeline for Initial Characterization of Bacterial Type III Secretion System Inhibitor Mode of Action Using Enteropathogenic Yersinia
Dozens of Gram negative pathogens use one or more type III secretion systems (T3SS) to disarm host defenses or occupy a beneficial niche during infection of a host organism.
October 31, 2018
Publications
The PARE Project: A Short Course-Based Research Project for National Surveillance of Antibiotic-Resistant Microbes in Environmental Samples
Course-based research experiences (CREs) have been proposed as an inclusive model to expose all students, including those at institutions without a strong research infrastructure, to research at an early stage.
October 12, 2018
Publications
Good Studies Evaluate the Disease While Great Studies Evaluate the Patient: Development and Application of a Desirability of Outcome Ranking Endpoint for Staphylococcus aureus Bloodstream Infection
Sarah B Doernberg, Thuy Tien Tram Tran, Steven Y C Tong, Mical Paul, Dafna Yahav, Joshua S Davis, Leonard Leibovici, Helen W Boucher, G Ralph Corey, Sara E Cosgrove, Henry F Chambers, Vance G Fowler, Scott R Evans, Thomas L Holland,
October, 2018
Publications
The landscape of intrinsic and evolved fluoroquinolone resistance in Acinetobacter baumannii includes suppression of drug-induced prophage replication
The emergence of fluoroquinolone resistance in nosocomial pathogens has restricted the clinical efficacy of this antibiotic class. In Acinetobacter baumannii, the majority of clinical isolates now show high level resistance due to mutations in gyrA (DNA gyrase) and parC (Topo IV).
October, 2018
Publications
Microbial Identification Using DNA Target Amplification and Sequencing: Clinical Utility and Impact on Patient Management
Tinzar Basein, Bradley J Gardiner, Gabriela M Andujar Vazquez, Andrew S Joel Chandranesan, Arthur R Rabson, Shira Doron, David R Snydman
Sep, 2018
Publications
Effect of Algorithm-Based Therapy vs Usual Care on Clinical Success and Serious Adverse Events in Patients with Staphylococcal Bacteremia: A Randomized Clinical Trial.
Thomas L. Holland, MD, Issam Raad, MD, Helen W. Boucher, MD, et al
August 27, 2018
Publications
The piglet acute diarrhea model for evaluating efficacy of treatment and control of cryptosporidiosis
Cryptosporidium spp. are ranked as the second leading pathogens causing life-threatening diarrhea in children under 2 years of age.
Aug, 2018
Publications
Antimicrobial susceptibility and ribotypes of Clostridium difficile isolates from a Phase 2 clinical trial of ridinilazole (SMT19969) and vancomycin.
Aug, 2018
Publications
Enhanced preservation of the human intestinal microbiota by ridinilazole, a novel Clostridium difficile-targeting antibacterial, compared to vancomycin.
Cheleste M. Thorpe , Anne V. Kane, Justin Chang, Albert Tai, Richard J. Vickers, and David R. Snydman
July 17, 2018
Publications
Stereospecific Synthesis of the Saccharosamine-Rhamnose-Fucose Fragment Present in Saccharomicin B
Marissa Bylsma and Clay S. Bennett
July, 2018
Publications
Accelerating Early Antituberculosis Drug Discovery by Creating Mycobacterial Indicator Strains That Predict Mode of Action
Maikel Boot, Susanna Commandeur, Amit K. Subudhi, Meriem Bahira, Trever C. Smith, II, Abdallah M. Abdallah, Mae van Gemert, Joël Lelièvre, Lluís Ballell, Bree B. Aldridge, Arnab Pain, Alexander Speer, Wilbert Bitter