Publications
September 10, 2019
Publications
Development Times and Approval Success Rates for Drugs to Treat Infectious Diseases
Joseph A. DiMasi, Ph.D., Maria I. Florez, MS, Stella Stergiopoulos, MS-MPH, Yaritza Peña, Zachary Smith, MA, Michael Wilkinson MPH, Kenneth A. Getz, MBATufts Center for the Study of Drug Development. Clin Pharmacol Ther. 2019 Sep 10.
September 1, 2019
Publications
Increasing Levels of Pretreatment HIV Drug Resistance and Safety Concerns for Dolutegravir Use In Women of Reproductive Age
Seth Inzaule; Michael Jordan; Amandine Cournil; Marco Vitoria; Giovanni Ravasi; Fatim Cham; Linh-Vi Le; Janet Dzangare; Ndapewa Hamunime; Nicholus Mutenda; Avelin Aghokeng; Annez Bissek; Serge Billong; Pontiano Kaleebu; Meg Doherty; Silvia Bertagnolio;. AIDS. 2019 Sep 1;33(11):1797-1799.
September 1, 2019
Publications
Effect of In-Line Drinking Water Chlorination at the Point of Collection on Childdiarrhoea in Urban Bangladesh: A Double-Blind, Cluster-Randomised Controlled Trial
Amy J Pickering, Yoshika Crider, Sonia Sultana, Jenna Swarthout, Frederick GB Goddard, Syed Anjerul Islam, et al. Lancet Glob Health. 2019 Sep;7(9):e1247-e1256.
August 10, 2019
Publications
RESTORE-IMI 1: A Multicenter, Randomized, Double-blind Trial Comparing Efficacy and Safety of Imipenem/Relebactam vs Colistin Plus Imipenem in Patients With Imipenem-nonsusceptible Bacterial Infections
Clin Infect Dis. 2019 Aug 10. pii: ciz530.
June 14, 2019
Publications
Acinetobacter baumannii: Envelope determinants that control drug resistance, virulence, and surface variability
Edward Geisinger, Wenwen Huo, Juan Hernandez-Bird, and Ralph R. Isberg. Annual Review of Microbiology Vol. 73:- (Volume publication date September. 2019); Review in Advance first posted online on June 14, 2019. (Changes may still occur before final publication.
May 17, 2019
Publications
Sequential, Multiple-Assignment, Randomized Trials for COMparing Personalized Antibiotic StrategieS (SMART-COMPASS)
Evans, S. R., D. Follmann, Y. Liu, T. Holland, S.B. Doernberg, N. Rouphael, T. Hamasaki, Y. Jiang, J. J. Lok, T.T.T. Tran, A.D. Harris, V.G. Fowler Jr, H. Boucher, B.N. Kreiswirth, R.A. Bonomo, D. van Duin, D.L. Paterson, and H. Chambers. Clin Infect Dis. 2019 May 17;68(11):1961-1967.
February, 2019
Publications
Promises and Challenges of the Type Three Secretion System Injectisome as an Antivirulence Target
Antibiotic resistance is a major public health threat that has stimulated the scientific community to search for nontraditional therapeutic targets. Because virulence, but not the growth, of many Gram-negative bacterial pathogens depends on the multicomponent type three secretion system injectisome (T3SSi), the T3SSi has been an attractive target for identifying small molecules, peptides, and monoclonal antibodies that inhibit its function to render the pathogen avirulent.
February 11, 2019
Publications
Provincial and National Prevalence Estimates of Transmitted HIV-1 Drug Resistance in South Africa Measured Using Two WHO-Recommended Methods
Gillian M Hunt, Johanna Ledwaba, Monalisa Kalimashe, Anna Salimo, Siyabonga Cibane, Beverly Singh, Adrian Puren, Natalie Exner Dean, Lynn Morris, Michael R Jordan. Antivir Ther. 2019;24(3):203-21.
February 4, 2019
Publications
Potassium Response and Homeostasis in Mycobacterium Tuberculosis Modulates Environmental Adaptation and is Important for Host Colonization
Nathan J. MacGilvary, Yuzo L. Kevorkian, and Shumin Tan. PLoS Pathog. 2019 Feb 4;15(2):e1007591.
January 30, 2019
Publications
Prediction of ultra-high-order antibiotic combinations based on pairwise interactions
Itay Katzir, Murat Cokol, Bree B. Aldridge, and Uri Alon. PLoS Comput Biol 15(1): e1006774.
January, 2019
Publications
Parenterally Administered Vancomycin in 29 Dogs and 7 Cats (2003-2017)
Ian M. DeStefano Annie S. Wayne Elizabeth A. Rozanski Jonathan M. Babyak
Jan, 2019
Publications
Prophage induction, but not production of phage particles, is required for lethal disease in a microbiome-replete murine model of enterohemorrhagic E. coli infection.
Enterohemorrhagic Escherichia coli (EHEC) colonize intestinal epithelium by generating characteristic attaching and effacing (AE) lesions. They are lysogenized by prophage that encode Shiga toxin 2 (Stx2), which is responsible for severe clinical manifestations.