Usage Patterns of Carbapenem Antimicrobials in Dogs and Cats at a Veterinary Tertiary Care Hospital
2019
Alison Smith, Annie S. Wayne, Claire L. Fellman, Marieke H. Rosenbaum. J Vet Intern Med. 2019 Jul;33(4):1677-1685.
Synthesis of the Non-Reducing Hexasaccharide Fragment of Saccharomicin B
November 14, 2018
ACS Publications, Organic Letters, 2018 Nov 14. doi: 10.1021/acs.orglett.8b03333
An Experimental Pipeline for Initial Characterization of Bacterial Type III Secretion System Inhibitor Mode of Action Using Enteropathogenic Yersinia
November, 2018
Dozens of Gram negative pathogens use one or more type III secretion systems (T3SS) to disarm host defenses or occupy a beneficial niche during infection of a host organism.
The PARE Project: A Short Course-Based Research Project for National Surveillance of Antibiotic-Resistant Microbes in Environmental Samples
October 31, 2018
Course-based research experiences (CREs) have been proposed as an inclusive model to expose all students, including those at institutions without a strong research infrastructure, to research at an early stage.
Good Studies Evaluate the Disease While Great Studies Evaluate the Patient: Development and Application of a Desirability of Outcome Ranking Endpoint for Staphylococcus aureus Bloodstream Infection
October 12, 2018
Sarah B Doernberg, Thuy Tien Tram Tran, Steven Y C Tong, Mical Paul, Dafna Yahav, Joshua S Davis, Leonard Leibovici, Helen W Boucher, G Ralph Corey, Sara E Cosgrove, Henry F Chambers, Vance G Fowler, Scott R Evans, Thomas L Holland,
The landscape of intrinsic and evolved fluoroquinolone resistance in Acinetobacter baumannii includes suppression of drug-induced prophage replication
October, 2018
The emergence of fluoroquinolone resistance in nosocomial pathogens has restricted the clinical efficacy of this antibiotic class. In Acinetobacter baumannii, the majority of clinical isolates now show high level resistance due to mutations in gyrA (DNA gyrase) and parC (Topo IV).
Microbial Identification Using DNA Target Amplification and Sequencing: Clinical Utility and Impact on Patient Management
October, 2018
Tinzar Basein, Bradley J Gardiner, Gabriela M Andujar Vazquez, Andrew S Joel Chandranesan, Arthur R Rabson, Shira Doron, David R Snydman
Effect of Algorithm-Based Therapy vs Usual Care on Clinical Success and Serious Adverse Events in Patients with Staphylococcal Bacteremia: A Randomized Clinical Trial.
Sep, 2018
Thomas L. Holland, MD, Issam Raad, MD, Helen W. Boucher, MD, et al
The piglet acute diarrhea model for evaluating efficacy of treatment and control of cryptosporidiosis
August 27, 2018
Cryptosporidium spp. are ranked as the second leading pathogens causing life-threatening diarrhea in children under 2 years of age.
Antimicrobial susceptibility and ribotypes of Clostridium difficile isolates from a Phase 2 clinical trial of ridinilazole (SMT19969) and vancomycin.
Aug, 2018
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