Publications

September 20, 2023
Publications
A US-based national surveillance study for the susceptibility and epidemiology of Clostridioides difficile isolates with special reference to ridinilazole: 2020–2021
D. R. Snydman, L. A. McDermott, C. M. Thorpe, E. J. C. Goldstein, A. N. Schuetz, S. Johnson, D. N. Gerding, L. Gluck, D. Bourdas, K. C. Carroll, C. K. Lancaster, K. W. Garey, Q. Wang, S. T. Walk, E. Duperchy

September 13, 2023
Publications
Checklist for studies of HIV drug resistance prevalence or incidence: rationale and recommended use
HIV drug resistance (HIVDR) is a major challenge to the effectiveness of antiretroviral therapy. Global efforts in addressing HIVDR require clear, transparent, and replicable reporting in HIVDR studies. We describe the rationale and recommended use of a checklist that should be included in reports of HIVDR incidence and prevalence. After preliminary consultations with experts on HIVDR and establishing the need for guidance on HIVDR reporting, we used a sequential, explanatory, mixed methods approach to create the checklist; together with the accompanying articles, the checklist was reviewed by the authors and validated externally. The checklist for studies on HIVDR prevalence or incidence (CEDRIC-HIV) includes 15 recommended items that would enhance transparency and facilitate interpretation, comparability, and replicability of HIVDR studies. CEDRIC-HIV will help authors of HIVDR studies prepare research reports and assist reviewers and editors in assessments of completeness of reporting. The checklist will also facilitate statistical pooling and interpretation of HIVDR data.

September 8, 2023
Publications
Leveraging the COVID-19 pandemic as a natural experiment to assess changes in antibiotic use and antibiotic-resistant E. coli carriage in semi-rural Ecuador
Heather K. Amato, Fernanda Loayza, Liseth Salinas, Diana Paredes, Daniela García, Soledad Sarzosa, Carlos Saraiva-Garcia, Timothy J. Johnson, Amy J. Pickering, Lee W. Riley, Gabriel Trueba & Jay P. Graham

August 22, 2023
Publications
Exploration of a Potential Desirability of Outcome Ranking Endpoint for Complicated Intra-Abdominal Infections Using 9 Registrational Trials for Antibacterial Drugs
Tori Kinamon, Ramya Gopinath, Ursula Waack, Mark Needles, Daniel Rubin, Deborah Collyar, Sarah B Doernberg, Scott Evans, Toshimitsu Hamasaki, Thomas L Holland, Jessica Howard-Anderson, Henry Chambers, Vance G Fowler, Jr, Sumati Nambiar, Peter Kim, Helen W Boucher

August 10, 2023
Publications
Interactions of Vibrio phages and their hosts in aquatic environments
Roberto C Molina-Quiroz, Cecilia A Silva-Valenzuela,
Bacteriophages (phages) are viruses that specifically infect bacteria. These viruses were discovered a century ago and have been used as a model system in microbial genetics and molecular biology. In order to survive, bacteria have to quickly adapt to phage challenges in their natural settings. In turn, phages continuously develop/evolve mechanisms for battling host defenses. A deeper understanding of the arms race between bacteria and phages is essential for the rational design of phage-based prophylaxis and therapies to prevent and treat bacterial infections. Vibrio species and their phages (vibriophages) are a suitable model to study these interactions. Phages are highly ubiquitous in aquatic environments and Vibrio are waterborne bacteria that must survive the constant attack by phages for successful transmission to their hosts. Here, we review relevant literature from the past two years to delve into the molecular interactions of Vibrio species and their phages in aquatic niches.

August 1, 2023
Publications
Prevalence of antibiotic use for dogs and cats in United States veterinary teaching hospitals, August 2020
Awareness of prescribing practices helps identify opportunities to improve antibiotic use (AU).

July 19, 2023
Publications
Chemical QuantArray: A Quantitative Tool for Mass Spectrometry Imaging
Sylwia A. Stopka, Daniela Ruiz, Gerard Baquer, Clément Bodineau, Md Amin Hossain, Valentina T. Pellens, Michael S. Regan, Olivier Pourquié, Marcia C. Haigis, Wenya L. Bi, Shannon M. Coy, Sandro Santagata, Nathalie Y. R. Agar, and Sankha S. Basu

July 1, 2023
Publications
Applying Desirability of Outcome Ranking End Points
Michael W Dunne, Steven I Aronin, Anita F Das, Jayanti Gupta, Karthik Akinapelli, Michael T Zelasky, Sailaja Puttagunta, Helen W Boucher

June 30, 2023
Publications
Evaluating the relationship between community water and sanitation access and the global burden of antibiotic resistance: an ecological study
Erica R Fuhrmeister, Abigail P Harvey, Maya L Nadimpalli, Karin Gallandat, Argaw Ambelu, Benjamin F Arnold, Joe Brown, Oliver Cumming, Ashlee M Earl, Gagandeep Kang, Samuel Kariuki, Karen Levy, Chris E Pinto Jimenez, Jenna M Swarthout, Gabriel Trueba, Pablo Tsukayama, Colin J Worby, Amy J Pickering

June 21, 2023
Publications
Establishing a baseline of antibiotic use in Massachusetts jails reveals heterogeneity in quantity of prescriptions and duration of therapy
Bart R Szewczyk, Rebecca Tenner, Emily Grussing, Maureen Campion, Gabriela Andujar Vazquez, Tara Bylsma, Shira Doron, Alysse G Wurcel

June 6, 2023
Publications
Novel Synergies and Isolate Specificities in the Drug Interaction Landscape of Mycobacterium abscessus
Nhi Van, Yonatan N. Degefu, Pathricia A. Leus, Jonah Larkins-Ford, Jacob Klickstein, Florian P. Maurer, David Stone, Husain Poonawala, Cheleste M. Thorpe, Trever C. Smith II, Bree B. Aldridge

June 5, 2023
Publications
Are fermented foods an overlooked reservoir of antimicrobial resistance?
Benjamin E. Wolfe
Despite their many cultural, culinary, and health benefits, fermented foods may amplify and disseminate antimicrobial resistance in our food supply. This review summarizes our current understanding of the diversity, distribution, and potential risks of antimicrobial resistance in fermented foods and beverages. Most studies have focused on antibiotic resistance genes (ARGs) in lactic acid bacteria and coagulase-negative Staphylococcus species. Resistance to tetracyclines, penicillins, chloramphenicol, and macrolides is frequently reported. Several studies have demonstrated that ARGs have the potential to be transferred from fermentation microbes to pathogens. Most research has used culture-based or metagenomic surveys or ARGs at the point of production, and few studies have traced the fate of ARGs when ferments are consumed. Cases of humans being directly harmed by resistant microbes in ferments have not been reported, but these foods provide a farm-to-gut pipeline for current and future antimicrobial resistance in our food supply.

