Associate Professor of One Health Diplomacy and Cummings Foundation One Health Professorship, TUFSLD

PhD

Director, Center for Molecular Medicine, Maine Health

PhD

Associate Professor of Molecular Biology & Microbiology, TUSM

PhD

Assistant Professor of Pathology (Anatomy), TUCSVM

DVM, MPH, PhD, DACVP

Professor of Molecular Biology & Microbiology, TUSM

PhD

My lab focuses on using bacteriophage therapy against antibiotic-resistant Gram-negative pathogens, primarily Vibrio cholerae, which is the causative agent of cholera.

Associate Professor of Biology, TUSAS; Co-Director of Science, Technology and Society

PhD

My lab has been using metagenomic sequencing to identify antibiotic resistance reservoirs in food systems, and we have also been working to identify how microbial interactions could drive the evolution of antibiotic resistance. More broadly, the research in my lab links ecological and evolutionary patterns in microbial communities with the molecular mechanisms that generate these patterns. Using tractable microbial communities from isolated from food systems, we have two broad research goals: identify the molecular mechanisms that control the assembly and function of microbial communities determine how microbial species evolve within multi-species communities. Our work will help develop principles of microbial community assembly that can guide the design and manipulation of microbial communities in agriculture, industry, medicine, and nature.

Vice Provost for Research; Professor of Immunology, TUSM

PhD, MBA

My research focuses on elucidating host-microbial interactions and the cellular and molecular mechanisms involved in the induction of immune responses against infectious diseases. My lab has provided insights into the development of vaccines against Chlamydia trachomatis, the leading cause of sexually transmitted bacterial disease, and the creation of a potential live attenuated vaccine against multidrug-resistant Acinetobacter baumannii, identified as an important nosocomial pathogen. Our research has also advanced several animal models for vaccine development against Francisella tularensis.

Associate Professor of Medical Education, TUSM; Director, Tufts University Center for Translational Science Education

PhD

Our work at CTSE engages future scientists and citizens in the science of health by fostering collaboration among biomedical scientists and high school educators. One of our projects focuses bring infectious diseases and AMR to high school classrooms across the country to increase science engagement and health literacy.

Provost & Senior Vice President, Tufts University; Arthur E Spiller Professor of Immunology, TUSM

PhD

My translational work has encompassed clinical studies evaluating immunological and microbiological responses following acute inflammatory diseases induced by sexually transmitted infections. Gonorrhea, caused Neisseria gonorrhoeae, is a disease of worldwide prevalence. The continued persistence and increased N. gonorrhoeae resistance to third generation cephalosporins is a warning for the development and spread of untreatable gonorrhea. One of our long-term goals is to develop a vaccine to treat sexually transmitted infections with emphasis on prevention of secondary complications in women.

Research Assistant Professor of Medical Education, TUSM

PhD

My work bridges environmental surveillance with education through a unique tracking program that engages undergraduates and high school students in classroom-based research activities to monitor resistance levels in environmental samples worldwide. Data contributed by students is curated and recorded in a GIS-based mapping system, providing researchers with an overview of potential hotspots of antimicrobial resistance.

Professor of Infectious Disease and Global Health, TUCSVM

PhD

My research focuses on the development and application of therapeutic biomolecules for treating a variety of diseases caused by pathogens such as C. difficile, Campylobacter, Vibrio cholera and various pathotypes of E. coli. Most of our therapeutic agents employ single domain antibody (sdAb) binding agents consisting of the VH region of heavy-chain-only Abs (VHHs) from immunized alpacas which have been selected for their ability to neutralize critical pathogen functions. These simple, stable VHH agents are then re-engineered in various ways to produce practical, cost-effective products with demonstrated potential to prevent or treat some diseases.

Assistant Professor of Small Animal Internal Medicine & Clinical Pharmacology, TUCSVM

PhD, DVM

I am a small-animal internist and clinical pharmacologist. I am part of a One Health collaboration with Annie Wayne, a veterinary criticalist at the Cummings School and fellow Levy CIMAR Core Faculty Member, as well as individuals at Tufts Medical Center. Together, we aim to bring human stewardship principles to companion animal veterinary medicine. I am also involved in clinical trials to provide evidence for appropriate antimicrobial treatment durations in veterinary patients.
As of 2023, I am the president-elect for ISCAID (International Society for Companion Animal Infectious Diseases), the group responsible for the most widely used antimicrobial guidelines.

Associate Professor of Chemistry, TUSAS

PhD

Research in my lab focuses on the synthesis of oligosaccharide antibiotics. These include compounds with broad spectrum activity against gram negative bacteria, as well as molecules that target Group B strep (GBS).

Professor of Civil & Environmental Engineering, TUSE

MPH, PhD, FACE

The working title of the doctoral dissertation of Kate Woodward, P.E., who I advise is “Removal of Antibiotic Residues and Control of Antibiotics Movement from Cattle Industry Wastewater in Nebraska.” Antibiotics used in livestock production to treat and prevent infections may impact human health by promoting development and excretion of resistant bacteria or genes in animal manure.

Assistant Professor, TUSM
Special Scientific Staff, TMC

PharmD, PhD

We have received NIH and DoD funding for research on the prophylaxis of babesiosis caused by Babesia microti, a protozoan parasite of red blood cells. We also work on a novel therapeutic approach to relapsing babesiosis, which often develops in immunocompromised patients and has been associated with antimicrobial resistance. Like Lyme disease, babesiosis develops following the bite of an infected deer tick. Babesia microti can also be transmitted through transfusion of contaminated blood components. Babesiosis is an emerging infectious disease in the Northeast and the upper Midwest of the United States, areas where Lyme disease has long been established.

Professor and Chair of the Division of Nutrition Data Sciences, TUFSN

Adjunct Professor of Civil and Environmental Engineering, TUSE; Public Health & Family Medicine, TUSM, Mathematics, TUSAS

PhD

Emerging and re-emerging diseases, environmental epidemiology, molecular biology, nutrition, and growth

Assistant Medical Director, Clinical Microbiology Laboratory; Attending Physician, TMC

MD

Assistant Professor of Biology, TUSAS

PhD

My lab studies the ecology and evolution of the vaginal microbiome with a focus on phage-bacteria and bacteria-bacteria interactions. We are investigating how phages drive evolution of resistance in their hosts, how bacteriocins and other antimicrobial compounds shape the bacterial community, and how phage therapy might be leveraged in this ecosystem to treat microbial syndromes such as bacterial vaginosis. We ultimately aim to use our work to design ecologically-informed microbial therapeutics for women’s health.

Frank C. Doble Professor of Biomedical Engineering; Dean of Research, TUSE

PhD

My research interests are in the convergence of technology, biologically inspired materials, and the natural sciences with an emphasis on new transformative approaches for sustainable materials for high-technology applications.

Dean, TUSM; Chief Academic Officer for Tufts Medicine

MD, FACP, FIDSA

My clinical interests include infections in immunocompromised patients and S. aureus infections, and my research interests focus on S. aureus and the development of new anti-infective agents. (Note: Dr. Boucher was Director of the Levy CIMAR along with Dr. Ralph Isberg from 2018-2021. Her work in antimicrobial resistance extends to education, policy, outreach, and more. She is a Fellow and Member of the Board of Directors of the Infectious Diseases Society of America, and is appointed to the Presidential Advisory Council on Combating Antibiotic-Resistant Bacteria, or PACCARB.)

Professor of Medicine, TUSM and TMC

MD

The intestinal parasite Cryptosporidium, (which is resistant to most antimicrobials including the classic antifolate antiparasitic drugs), is a major cause of diarrheal disease worldwide, particularly in immunocompromised hosts such as untreated patients with HIV/AIDS and malnourished children in resource-limited settings. Our research is focused on: 1) understanding the pathogenesis of human Cryptosporidium infection using novel bioengineered 3D intestinal tissue models; 2) the molecular basis of Cryptosporidium-host cell interactions, seeking to investigate proteins which mediate these interactions and enzymes that post-translationally modify them; 3) immune responses to Cryptosporidium in children in resource-limited settings where cryptosporidiosis is endemic; and 4) the intestinal microbiome in infectious diarrheal disease including childhood cryptosporidiosis and malnutrition. 5) understanding of recovery after post-acute sequelae of SARS-CoV-2 infection in adults.

Attending Physician; Assistant Director of the Clinical Microbiology Laboratory, TMC

MBBS, MPH

My research focuses on tuberculosis and non-tuberculous mycobacteria, and I am interested in studying how next-generation sequencing and novel diagnostic methods can be integrated into clinical care and public health interventions that can be used to improve outcomes from these infections.

Assistant Clinical Professor, Department of Clinical Sciences, TUCSVM

DVM, DACVECC

I am a small animal veterinary emergency and critical care specialist. Along with Dr. Claire Fellman, I co-chair the Infection Control and Antimicrobial Stewardship Team (ICAST) at the Foster Hospital for Small Animals. My clinical and research interests include management of multidrug-resistant infections in dogs and cats, as well as infection prevention strategies for organisms such as carbapenem-resistant Enterobacterales, an emerging threat in small animal patients.

Professor of Molecular Biology & Microbiology, TUSM

PhD

My lab investigates factors required for Klebsiella pneumoniae to cause disease in lungs, blood, liver and bladder, as well as genetic, host-derived, and chemical factors that render multi-drug resistant Klebsiella more susceptible to treatment.

Professor of Infectious Disease and Global Health, TUCSVM

DVM, PhD

My lab seeks to understand genetic factors that impact susceptibility to infectious disease, specific or general and the repercussions for potential epidemics, persistence, and evolution of those infectious agents. Using a combination of our own field samples, collaborations and published genomic data, we are developing tools to investigate correlates of influenza disease resistance and/or susceptibility among multiple species. We seek to provide unbiased host factors associated with viral resistance/susceptibility while contributing valuable tools for all investigators.

Attending Physician in Geographic Medicine and Infectious Diseases, TMC; Assistant Professor of Medicine, TUSM.

MD

I am an infectious diseases clinician and clinical researcher. My research interests include antimicrobial and diagnostic stewardship in acute care, long-term care, and OPAT (outpatient parenteral antimicrobial therapy) care settings.

PhD

I coordinate with the Levy CIMAR leadership team, members, and other collaborators to plan and advance our research agenda, which is focused on developing new and better antimicrobial regimens for a range of microbes and infection types, as well as strategies to combat antimicrobial resistance based on improved understanding of how it develops and spreads. I lead efforts in designing, optimizing, and troubleshooting assays and analysis pipelines, and generate data to address our specific research aims, support collaborations, and advance new projects. I also help our collaborators address experimental design, protocol, and analysis questions related to the antibiotic testing methodology used and developed through CIMAR, and provide certain assistance and training in these areas where needed.

Assistant Professor of Medicine, Division of Gastroenterology, TMC

PhD

I am a computational biologist researching the relationship between the gut microbiome and human health, and developing software tools for making sense of large datasets. Departing from the traditional approach of validating animal model data in humans, I instead employ bioinformatic modeling to analyze human metagenomic and neurodevelopmental data, generating hypotheses for subsequent testing in animal models.

Robinson Professor of Chemistry, TUSAS; Professor of Biomedical Engineering, TUSE

PhD

I am interested in the molecular design of structural scaffolds for discovering new antimicrobial compounds especially those against resistant organisms, as well as the use of organic chemistry, biological chemistry, biophysics, and cellular biology to understand mechanism of action of therapeutically relevant antibiotics.

Dean Ad Interim and Karol Family Professor of Chemical and Biological Engineering; Tissue and Metabolic Engineering Laboratory, TUSE

PhD

My research interests include metabolic engineering, tissue engineering, and systems biology, as well as the study of cellular metabolism and its role in shaping biological function. A major ongoing effort is to investigate metabolites that mediate chemical communication between bacterial gut microbiota and the host.

Paul and Elaine Chervinsky Professor in Immunology and Vice Dean for Research, TUSM

MD

Fellow in Geographic Medicine and Infectious Diseases, TMC

MD

Research Assistant Professor, TUCSVM

DVM, MPH, MS

My research focuses on understanding how domestic and wild animals such as backyard chickens and city rats contribute to the spread of AMR genes in urban centers.

Senior Clinical Pharmacy Specialist in Infectious Diseases, TMC

PharmD, BCIDP

Attending Physician, TMC;
Assistant Professor, TUSM

MD, MPH

I study HIV drug resistance and translate results into public health and antiretroviral therapy program policy in low- and middle-income countries. In addition, my laboratory studies inter- and intra-host diversity of SARS-CoV-2 and SARS-CoV-2 antiviral drug resistance.

Assistant Professor of Chemical & Biological Engineering, TUSE

PhD

The Nair lab is interested in using the tools of synthetic and chemical biology to understand the effect of antimicrobials on the structure and function of microbial communities.

Research assistant professor, TUSM; Director for Translational Research, Tufts University Lyme Disease Initiative

PhD

I study the molecular mechanisms the bacterium Borrelia burgdorferi, which causes Lyme disease, uses to transition between different hosts such as ticks, mice, and humans. My research aims to exploit these unique metabolic interactions to design targeted drugs for Lyme disease.

Associate Professor of Biomedical Engineering, TUSE,
Associate Professor, TUSM

PhD

Developing synthetic materials for the delivery of therapeutic biomacromolecules

Assistant Professor of Medical Education, TUSM

PhD

I serve as Director of the Lab Science Investigators Program on AMR, Director of the Great Diseases curriculum, and Co-Director of the Mini-Med Connect Programs for pre-college learners at the Center for Science Education at Tufts University. I also teach immunology in the professional programs at Tufts University School of Medicine. After my doctoral work in Immunology and a postdoctoral fellowship in Infectious Disease, I trained in curriculum design and evaluation in the domain of biomedical education. I have experienced science education from the prism of having designed curriculum for, and teaching, a wide spectrum of learners from high school students, K-12 educators, medical students, and graduate students. My research focuses on models to strengthen engagement with science and health awareness in adolescent populations through inclusive, equitable teaching practices.

Attending Physician, Associate Hospital Epidemiologist, and Antimicrobial Steward, TMC; Professor of Medicine, TUSM

MD

My research focuses on the implementation of antimicrobial stewardship strategies in human acute care, human long term care, and animal care settings.

Assistant Professor of Molecular Biology & Microbiology, TUSM

PhD

My lab’s research centers on understanding how Mycobacterium tuberculosis exploits environmental cues to survive and grow in its host. As part of this focus, we seek to (i) elucidate regulatory nodes that enable the bacterium’s coordinated response to disparate cues and that thus represent novel therapeutic targets in both drug-sensitive and drug-resistant bacteria, and (ii) understand how microenvironment heterogeneity impacts infection outcome and treatment efficacy.

Research Assistant Professor, TUSM

PhD

In my research, I use a combination of fluorescence microscopy, omics style data, and computational biology to understand how drugs target and kill Mycobacterium tuberculosis (Mtb). Using antibacterials to inhibit specific cellular processes, I am currently investigating how perturbations to one or more pathways contribute to Mtb cell death.

Associate Professor of Molecular Biology and Microbiology, TUSM

Our research focuses on the molecular mechanisms underlying quorum sensing and cyclic oligonucleotide–based signaling in bacteria. These pathways play central roles in antibiotic resistance, virulence, biofilm formation, horizontal gene transfer, and antiviral defense in many drug-resistant pathogens. By elucidating the fundamental biology of these systems, we aim to inform new strategies for combating infectious diseases that are poorly treated by conventional antibiotics.

Associate Professor of Medicine, TUSM; Attending Physician, TMC

MD, FIDSA

I investigate the risk factors for infections by antibiotic-resistant organisms and develop scores to target certain patients for therapy for such organisms. My research focuses on infections by resistant Gram negative pathogens, C. difficile, and other hospital-acquired pathogens.