As a practicing ID physician and scientist, Dr. Thorpe’s research includes translational work assessing the impact of antimicrobials on human gastrointestinal microbiota and metabolome, with a specific focus on treatment of C. difficile infection.  She is interested in how microbial communities shift in response to disease and antibiotic treatments, and how those shifts may predispose to colonization with antibiotic resistant organisms or have other deleterious impacts. She is also interested in host-pathogen interactions with a particular focus on Shiga toxin-producing E. coli.